Cardiac Cellular Electrophysiology

Leader: Arie Verkerk

Expertise

Dr. Arie O. Verkerk and group members have worked on basic mechanisms of cardiac electrical activity, excitation-contraction coupling, arrhythmias, and heart failure, with particular emphasis on cardiac ion channels, ion exchangers and impulse propagation (Click here for publications by this research group). The deep and integrative understanding of cellular electrophysiology and ion transport systems of the group members is essential for the multidisciplinary cardiovascular research of the recently formed Heart Failure Research Center (HFRC). Specifically, the expertise of the group members covers a wide range of the functional aspects of the various cardiac cell types and constitutes the link between ‘clone’ (molecular biology, proteomics, genetics, cardiac embryology) and ‘clinic’. Accordingly, research is conducted in close collaboration with basic scientists on one hand and clinicians on the other hand. Ongoing research centers around basic mechanisms of cardiac pacemaking. Using sophisticated and novel techniques for ion channel function studies (e.g. dynamic action potential clamp), mathematical cell models, and various transgenic mouse models, the molecular and cellular mechanisms of cardiac pacemaking are studied during development, aging and disease.

Team members

namefunction
Arie VerkerkGroup Leader
Antoni van GinnekenScientist
Ronald WildersScientist
Berend de JongeTechnician

Key publications