Cardiac arrhythmias; mechanism & treatment

Leader: Jacques de Bakker

Expertise

Cardiac disease is accompanied by structural and electrical remodeling of the myocardium, disease-induced changes of the myocardium that may lead to cardiac arrhythmias. Cardiac disease may be acquired as found in ischemia or inherited as present in primary ion channelopathies like Brugada-syndrome and in some forms of ARVC

Goals

  • Unravel at the electrophysiological and molecular biological level the substrate that leads to impaired electrical stability of the heart
  • Develop ways to compensate for the adverse effects of remodeling and treat the associated rhythm disorders

Most studies are carried out in collaboration with various ICIN-centers. Projects include:

  • Mechanism of arrhythmias
  • Parameters determining conduction
  • Molecular markers to predict arrhythmias
  • Mechanism of Brugada syndrome and ARVC
  • Non-invasive techniques to assess arrhythmia vulnerability
  • Characteristics of cardiac progenitor cells
  • Treatment of arrhythmias
  • Development of a biopacemaker
  • Molecular ablation of tachycardias
  • Silencing of ion channel mutations

Team members

namefunction
Jacques de BakkerGroup Leader (PI)
Shirley van AmersfoorthTechnician

Key publications