Pathophysiologic Mechanisms of Sudden Death

Leader: Hanno Tan


  • Biophysical analysis of mutant sarcolemmal ion channels associated with inherited arrhythmia syndromes, in particular, patch-clamp analysis of sodium channels
  • Cardiogenetics outpatient clinic: analysis and treatment of tertiary referrals for inherited arrhythmia syndromes (e.g., Brugada syndrome, inherited and acquired Long QT syndrome, Short QT syndrome, catecholaminergic polymorphic ventricular tachycardia) and cardiomyopathies (hypertrophic and dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy)
  • Clinical cardiology and clinical electrophysiology: clinical studies into arrhythmia mechanisms and treatments in patients with inherited disease (e.g., inherited Long QT syndrome, Brugada syndrome) and common acquired disease (e.g., atrial fibrillation)

Current research

  • Population-based study of environmental determinants (e.g., drug use, concomitant cardiac or noncardiac disease) and genetic determinants of sudden cardiac death
  • Electrophysiologic and molecular basis of enhanced arrhythmia susceptibility, e.g., secondary to blood platelet activation or adrenergic stimulation
  • Pathophysiologic mechanisms and novel treatments for right ventricular disease
  • Development of biologic pacemaker by genetic engineering

Team members

Hanno TanGroup Leader (PI)
Iris OvingPhD student
Laura van DongenPhD student
Marieke BlomPhD student

Key publications