The organisation is structured around leading scientists and their groups. The underlying philosophy is that individuals are most productive when working on projects on which they develop their own 'passion'. This is best achieved in a network organisation, in which the leading scientists and their groups are central and form focused research lines that share knowledge, but are, nonetheless, responsible for their own 'scientific healthiness'. The director of the center organizes appropriate research meetings, is responsible for the infrastructure, and commits substantial energy to encourage research collaborations. We recognise that integration of the multi-faceted research findings is an essential prerequisite for practical application.